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Andrea CuconatiAndrea Cuconati, Ph.D.

Andrea Cuconati, Ph.D., has a primary background in molecular virology. He earned his doctorate under the guidance of Dr. Eckard Wimmer at the Medical School of the State University of New York at Stony Brook, where he worked on elucidating how the fungal toxin brefeldin A, an inhibitor of cellular secretory transport, also inhibits the replication of poliovirus. His doctoral work contributed to the understanding of the basic biology of an important family of human pathogens.

Dr. Cuconati moved to a post-doctoral position in the laboratory of Dr. Eileen White at the Howard Hughes Medical Institute and the Center for Advanced Biotechnology and Medicine in New Jersey, where he helped to elucidate the mechanisms by which the oncogenic proteins of adenoviruses control the cell cycle and programmed cell death. His post-doctoral research contributed to the overall model of how DNA viruses cause some types of cancer.

After joining ViroPharma, Inc., in Pennsylvania, Dr. Cuconati developed and adapted several assays for industrial high-throughput screening (HTS) of large compound libraries. During his time in industry, he led successful efforts to discover drug candidates for the treatment of Ebola and Lassa hemorrhagic fevers, two devastating diseases endemic to Sub-Saharan Africa. Dr. Cuconati also contributed to drug discovery efforts for the treatment of respiratory syncytial virus and rotavirus, the causative agents of two common childhood illnesses. He is the author or coauthor of several primary research papers and reviews, and has 12 years of post-graduate experience in molecular virology and antiviral drug research.

 

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