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Patrick Y. Lam, Ph.D.

lam Patrick Lam is currently a medicinal chemistry and drug discovery consultant at Lam Drug Discovery Consulting, LLC. He is an Adjunct Professor at both the Drexel University College of Medicine and the Institute for Hepatitis and Virus Research. He is also an Associate Professor of Chemistry in Pennsylvania Drug Discovery Institute. He has over 27 years of research experience. Patrick was formerly a director in the Discovery Chemistry Department at Bristol-Myers Squibb Co. He started his career in DuPont in 1984 and moved to BMS in 2001. In recent years, he has been involved with antithrombotics, HIV protease inhibitors and PCSK9 antisense oligonucleotide (ASO) therapeutics.
Patrick has discovered a total of eight clinical candidates by leading groups or personal effort. He was the group leader/director responsible for the discovery of Eliquis®/Apixaban, a novel FXa inhibitor as a new anticoagulant medicine. Eliquis® has been approved for marketing in EU since May 2011. Eliquis® is projected by investment analysts to potentially achieve ~$5 billion annual peak sale. Patrick is also the inventor of the novel cyclic urea HIV protease inhibitors which led to the discovery of Mozenavir/DMP450. In Phase II trial, Mozenavir was found to be as effective as Merck's Crixivan.
Patrick is also internationally known as the co-discoverer of the powerful Chan-Lam Coupling Reaction. This is the copper-promoted oxidative coupling reaction for N/O-arylation with arylboronic acids. Chan-Lam Coupling is complementary to the 2010 Nobel Prize winning Suzuki-Miyaura C-C bond Coupling Reaction.
Patrick has authored 83 papers/reviews/book chapters and is an inventor on 39 patents/patent applications. He has presented 69 invited seminars worldwide. Patrick has received numerous awards including BMS Ondetti-Cushman Innovation Award for FXa inhibitor discovery in 2003 and the DuPont-Merck Summit Award for the discovery of cyclic ureas as HIV protease inhibitor capable of displacing the “structured water”  in 1993. He serves on the Editorial Board of Current Medicinal Chemistry, Medicinal Chemistry, Letters in Drug Design & Discovery, Medicinal Research Review.
Patrick received his Ph.D. from the University of Rochester (Dr. Louis Friedrich) and was a postdoctoral fellow in UCLA (Prof. Mike Jung and the late Prof. Don Cram, 1987 Nobel Laureate).

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