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Bruce E. Marynoff , Ph.D.

Dr. Bruce E. Maryanoff was born in Philadelphia, Pennsylvania.  He earned a B.S. in chemistry (1969) and a Ph.D. in organic chemistry (1972) from Drexel University.  After postdoctoral studies at Princeton University, he joined McNeil Laboratories, a Johnson & Johnson company.  He advanced on the scientific ladder in various Johnson & Johnson pharmaceutical units to the highest scientific position, Distinguished Research Fellow.  He retired in 2010, after 36 years, and is now affiliated with The Scripps Research Institute (La Jolla, CA), the Pennsylvania Drug Discovery Institute (Doylestown, PA), and the Institute for Hepatitis and Virus Research (Doylestown).
      Dr. Maryanoff has made numerous contributions in medicinal and organic chemistry.  He is an internationally renowned expert in drug design and drug discovery.  From 1976-1992, he worked on central nervous system therapeutics, focusing on anticonvulsants and antidepressants.  Dr. Maryanoff discovered and championed TOPAMAX® topiramate, a unique sugar sulfamate, used worldwide for treating epilepsy and migraine headache, achieving peak sales of >$2 billion/year.  Topiramate is a main component of VIVUS’s antiobesity drug Qsymia.  From 1991-2010, he pursued therapeutics for cardiovascular disease, metabolic disorders, epilepsy, and pulmonary inflammation.  Since 1990, his drug research has dealt with structure-based drug design; peptides/peptidomimetics; enzyme inhibitors, especially for serine proteases and kinases; integrin antagonists; and ligands for G-protein-coupled receptors.  His efforts led to 23 compounds entering preclinical development, 13 of which advanced into human clinical trials.  In organic chemistry, he made seminal contributions to the stereochemistry and mechanism of the Wittig olefination reaction and adapted cobalt-mediated [2+2+2] alkyne cyclotrimerizations to macrocycle synthesis.  Dr. Maryanoff has published 275 scientific papers, is an inventor on 100 U.S. Patents (issued or pending), has presented 175 invited lectures, and has mentored 11 postdoctoral associates.
      Dr. Maryanoff is Associate Editor of ACS Medicinal Chemistry Letters and has served on many journal Editorial Advisory Boards.  He has organized and chaired numerous symposia, at ACS national/regional meetings, an AAAS national meeting, and Gordon Research Conferences.  He edited the book series Advances in Medicinal Chemistry and two special issues of J. Med. Chem.
      Dr. Maryanoff has received three American Chemical Society (ACS) national awards, the Heroes of Chemistry Award-2000, Award in Industrial Chemistry-2003, and E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances-2013; also the 2009 Edward E. Smissman Award from the ACS Division of Medicinal Chemistry.  He was inducted into the ACS Medicinal Chemistry Hall of Fame in 2008.  Dr. Maryanoff was elected Fellow of the American Association for the Advancement of Science (1989), the Royal Society of Chemistry (2000), and the ACS (2009; inaugural year). 


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